Cannabinoids are wonderful compounds with one very big problem–they are lipophilic, or fat loving. This makes dosing very, very tricky. And why it’s so hard to measure cannabinoid levels in the blood and urine. The pharmacokinetics and pharmacodynamics of cannabinoids are greatly affected by various factors, such as the amount and type of food eaten in a given day, whether other substances, including medications, were taken, and how they were consumed (vape, oil, edible, etc.). For these reasons and more, despite decades of research, the best advice to offer new users remains the “start low, go slow” method, which is as unscientific as it comes. And explains why this topic remains red hot in research.
Cohin Kakar Pharm. D., MBA